News 44 : réanimation des nouveaux-nés et retard mental

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News 44 : réanimation des nouveaux-nés et retard mental

Message par Bull » mar. mai 05, 2009 3:41 pm

Les techniques de réanimation pédiatrique sont en constant progrès et les prématurés sont réanimés de plus en plus "jeunes".
Pourtant nous n'avons pas encore de recul suffisant pour évaluer les conséquences sur le long terme de ces réanimations.
Ici, le résultat d'un suivi d'enfants réanimés à la naissance, alors qu'ils n'étaient PAS prématurés.
Et bien, qu'ils aient eu ou pas des signes précoces d'en céphalopathie, ils sont à risque d'avoir un "QI bas".
Alors je sais, la notion de QI et tout ça. Mais nous parlons ici d'un QI inférieur à 80.

Je n'en tire évidemment aucune conclusion personnelle, et ce n'est PAS une étude sur le suivi des très grands prématurés (exemple, naissance au bout de 24 semaines), mais je suis assez inquiet de voir dans les années à venir le suivi des ces enfants, car si "même non prématurés et sans signes de souffrance cérébrale" il y a "risque", que cela va t'il "donner" pour eux ???

Avis, vraiment personnel, non scientifique, purement intuitif etc..., est-ce que nous n'avons pas un peu trop joué aux "sorciers" avec nos nouvelles techniques de réanimation super-efficaces ?

Lancet. 2009 Apr 20.

Resuscitation at birth and cognition at 8 years of age: a cohort study.

Odd DE, Lewis G, Whitelaw A, Gunnell D.

Clinical Science at North Bristol, University of Bristol, Bristol, UK.


BACKGROUND:
Mild cerebral injury might cause subtle defects in cognitive function that are only detectable as the child grows older. Our aim was to determine whether infants receiving resuscitation after birth, but with no symptoms of encephalopathy, have reduced intelligence quotient (IQ) scores in childhood.
METHODS:
Three groups of infants were selected from the Avon Longitudinal Study of Parents and Children: infants who were resuscitated at birth but were asymptomatic for encephalopathy and had no further neonatal care (n=815), those who were resuscitated and had neonatal care for symptoms of encephalopathy (n=58 ), and the reference group who were not resuscitated, were asymptomatic for encephalopathy, and had no further neonatal care (n=10 609). Cognitive function was assessed at a mean age of 8.6 years (SD 0.33); a low IQ score was defined as less than 80. IQ scores were obtained for 5953 children with a shortened version of the Weschler intelligence scale for children (WISC-III), the remaining 5529 were non-responders. All children did not complete all parts of the test, and therefore multiplied IQ values comparable to the full-scale test were only available for 5887 children. Results were adjusted for clinical and social covariates. Chained equations were used to impute missing values of covariates.
FINDINGS: In the main analysis at 8 years of age (n=5887), increased risk of a low IQ score was recorded in both resuscitated infants asymptomatic for encephalopathy (odds ratio 1.65 [95% CI 1.13-2.43]) and those with symptoms of encephalopathy (6.22 [1.57-24.65]). However, the population of asymptomatic infants was larger than that of infants with encephalopathy, and therefore the population attributable risk fraction for an IQ score that might be attributable to the need for resuscitation at birth was 3.4% (95% CI 0.5-6.3) for asymptomatic infants and 1.2% (0.2-2.2) for those who developed encephalopathy.
INTERPRETATION: Infants who were resuscitated had increased risk of a low IQ score, even if they remained healthy during the neonatal period. Resuscitated infants asymptomatic for encephalopathy might result in a larger proportion of adults with low IQs than do those who develop neurological symptoms consistent with encephalopathy.
et je rajoute aussi cette phrase du Materiel et methode indiquant qu'ils ne s'agit PAS de prématurés.
11 981 singleton infants, born at or after 36 weeks' gestation at two major maternity units in the study area, and alive at 8 years of age (figure), were selected from the Avon Longitudinal Study of Parents and Children (ALSPAC).

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